They come as an over-the-counter supplement and as a more purified and concentrated prescription formulation.
Since unbound cholesterol is amphipathic, it is transported along with phospholipids and proteins in the monolayer surface of the lipoprotein particle.
Herein lies one potential for numerous side effects, because statin drugs inhibit not just the production of cholesterol, but a whole family of intermediary substances, many if not all of which have important biochemical functions in their own right.